Syphilis in Pregnancy and Congenital Syphilis - Minnesota Dept. of Health

Syphilis in Pregnancy and Congenital Syphilis

Information for health professionals on working with pregnant people.

On this page:
Provider's Role
Fact Sheets

Untreated syphilis in pregnant people can lead to low birth weight, early delivery or stillbirth, baby's death shortly after birth, and/or lifelong health problems.

Provider's Role


Effective prevention and detection of congenital syphilis depends on the identification of syphilis in pregnant people, and therefore, on the routine serologic screening of pregnant people during the first prenatal visit.

The following are scenarios related to the congenital syphilis evaluation and treatment of infants born to pregnant people who have reactive serologic tests for syphilis during pregnancy.

  • Scenario 1: Proven or highly probable congenital syphilis
  • Scenario 2: Possible congenital syphilis
  • Scenario 3: Congenital syphilis is less likely
  • Scenario 4: Congenital syphilis unlikely

For more detailed evaluation and treatment information, please see Congenital Syphilis.


Syphilis Serology Algorithm (PDF)


Syphilis Screening During Pregnancy (PDF)
One-page summary of syphilis screening guidelines during pregnancy.

Clinical Guidelines for Syphilis during Pregnancy and Congenital Syphilis, Including Infants and Children (PDF)
Clinical guidelines for syphilis during pregnancy, congenital syphilis, and syphilis in infants and children. Revised February 2019.


Providers must report cases of syphilis, including congenital syphilis.

Fact Sheets


Updated Wednesday, 25-Aug-2021 15:59:58 CDT